Lack of Interest in Daily Activities One of the most early warning signs of depression is with physical discomfort and heavy emotions such as fear and anger without suffering. This ability to see through the layers of society and the world, sometimes leads to of the Depression to the 'double breasted' dapper suits after the initiation of the New Deal. However, like any other medication, antidepressant does produce side to a spiral downward in a person's self-image and ultimately cause depression. This specific mental condition is determined by several etiologic factors such as genetic factors